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Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital's surgical unit. Unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.

Adrian Monk was once a rising star with the San Francisco Police Department, legendary for using unconventional means to solve the department's most baffling cases. But after the tragic (and still unsolved) murder of his wife Trudy, he developed an extreme case of obsessive-compulsive disorder. Now working as a private consultant, Monk continues to investigate cases in the most unconventional ways.

The Division is an American crime drama television series created by Deborah Joy LeVine and starring Bonnie Bedelia. The series focused on a team of women police officers in the San Francisco Police Department. The series premiered on Lifetime on January 7, 2001 and ended on June 28, 2004 after 88 episodes.

When an assassin's bullet confines him to a wheelchair for life ending his career as Chief of Detectives, Robert T. Ironside becomes a consultant to the police department. Detective Sergeant Ed Brown and policewoman Eve Whitfield join with him to crack varied and fascinating cases. Ex-con Mark Sanger is employed by the chief as home help but eventually becomes a fully fledged member of the team also. Officer Whitfield leaves after 4 years service, and is replaced by Officer Fran Belding.

Half & Half is an American sitcom that aired on UPN from September 23, 2002, to May 15, 2006. The show focuses on the lives of two paternal half-sisters in their twenties who were estranged throughout their childhood, and are finally developing a close relationship. The series is set in San Francisco. It was the second-most-watched show on UPN's Monday night line-up and fourth overall on the network. The show was on The CW's first draft line-up in March 2006, but due to several circumstances—including The CW's contractual obligation to pick up Reba, the uncancelling of All of Us, and the pick-up of the Girlfriends spin-off The Game—Half & Half was left off the final Fall 2006 schedule and ended production. The series has aired in reruns on Global TV in Canada, Trouble in the UK and in local syndication in the United States. It also airs in the United States on TV One.

Crazy Like a Fox is an American television series set in San Francisco, California, that aired on CBS from December 30, 1984 to May 3, 1986.

No ordinary teenager; Raven Baxter can see glimpses of the future! Watch her schemes and misadventures as she enlists the help of friends, including best friends Eddie and Chelsea, to change life's little outcomes. Raven's younger brother, Cory, is obsessed with money and creates get-rich-quick schemes to try to earn cash.

A gritty, action-packed crime drama set during the brutal Tong Wars of San Francisco’s Chinatown in the second half of the 19th century. The series follows Ah Sahm, a martial arts prodigy who immigrates from China to San Francisco under mysterious circumstances, and becomes a hatchet man for one of Chinatown’s most powerful tongs.

Fun-loving San Francisco Police Department investigator Nash Bridges is part of the elite Special Investigations Unit. He tackles crime using his keen sense of humor and charm. Joe Dominguez comes out of retirement to become Bridges' wisecracking yet more rule-abiding partner.

After an unusual event, Zoey Clarke, a whip-smart computer coder forging her way in San Francisco, suddenly starts to hear the innermost wants, thoughts and desires of the people around her through popular songs.

Five brothers and sisters are determined to stay together following the tragic loss of their parents.

D.J. Tanner-Fuller is a widow and mother of three. Things become too much to handle, so she asks for help from her sister Stephanie and her best-friend Kimmy.

Hotel is an American prime time drama series which aired on ABC from September 21, 1983 to May 5, 1988 in the timeslot following Dynasty. Based on Arthur Hailey's 1965 novel of the same name, the series was produced by Aaron Spelling and set in the elegant and fictitious St. Gregory Hotel in San Francisco. Establishing shots of the hotel were filmed in front of The Fairmont San Francisco atop the Nob Hill neighborhood. Episodes followed the activities of passing guests, as well as the personal and professional lives of the hotel staff.

Chyna Parks, an 11 year old musical prodigy, gets into a gifted program called Advanced Natural Talents at the local high school. Along with her fellow elementary school-aged 'ANTs', she must navigate the halls of a new school of older kids who are not particularly fond of grade-skipping newbies.

Murder in the First follows homicide detectives Terry English and Hildy Mulligan as they investigate a multitude of tragedies in San Francisco.

The last in a line of Chosen Ones, a wannabe chef teams up with a homicide detective to unravel an ancient mystery and take down supernatural assassins.

Trapper John, M.D. is an American television medical drama and spin-off of the film MASH, concerning a lovable doctor who became a mentor and father figure in San Francisco, California. The show ran on CBS from September 23, 1979, to September 4, 1986.

Mary Ann returns to present-day San Francisco and is reunited with her daughter and ex-husband, twenty years after leaving them behind to pursue her career. Fleeing the midlife crisis that her picture-perfect Connecticut life created, Mary Ann is quickly drawn back into the orbit of Anna Madrigal, her chosen family and a new generation of queer young residents living at 28 Barbary Lane.

Dharma & Greg is an American television sitcom that aired from September 24, 1997, to April 30, 2002. It stars Jenna Elfman and Thomas Gibson as Dharma and Greg Montgomery, a couple who got married on their first date despite being complete opposites. The series is co-produced by Chuck Lorre Productions, More-Medavoy Productions and 4 to 6 Foot Productions in association with 20th Century Fox Television for ABC. The show's theme song was written and performed by composer Dennis C. Brown. Created by executive producers Dottie Dartland and Chuck Lorre, the comedy took much of its inspiration from so-called culture-clash "fish out of water" situations. The show earned eight Golden Globe nominations, six Emmy Award nominations, and six Satellite Awards nominations. Elfman earned a Golden Globe in 1999 for Best Actress.

Laura Price, a local news producer in San Francisco, is helping the police to hunt down a serial killer. After the killer strikes close to home, a twist of fate allows a “Groundhog Day”-type reset, and Laura relives the week prior to the string of murders. Can she change fate and stop the killer?